Kutyna, Dariusz R.; Onetto, Cristobal A.; Williams, Thomas C.; Goold, Hugh D.; Paulsen, Ian T.; Pretorius, Isak S.; Johnson, Daniel L.; Borneman, Anthony R. published the artcile< Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome>, Name: D-Glucosaccharic acid, the main research area is Saccharomyces pan genome neo chromosome genetic diversity phenotypic plasticity.
The Synthetic Yeast Genome Project (Sc2.0) represents the first foray into eukaryotic genome engineering and a framework for designing and building the next generation of industrial microbes. However, the laboratory strain S288c used lacks many of the genes that provide phenotypic diversity to industrial and environmental isolates. To address this shortcoming, we have designed and constructed a neo-chromosome that contains many of these diverse pan-genomic elements and which is compatible with the Sc2.0 design and test framework. The presence of this neo-chromosome provides phenotypic plasticity to the Sc2.0 parent strain, including expanding the range of utilizable carbon sources. We also demonstrate that the induction of programmable structural variation (SCRaMbLE) provides genetic diversity on which further adaptive gains could be selected. The presence of this neo-chromosome within the Sc2.0 backbone may therefore provide the means to adapt synthetic strains to a wider variety of environments, a process which will be vital to transitioning Sc2.0 from the laboratory into industrial applications.
Nature Communications published new progress about Biofuels. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts