In 2011,Krishna Reddy, V. V. R. M.; Udaykiran, D.; Chintamani, U. S.; Mahesh Reddy, E.; Kameswararao, Ch.; Madhusudhan, G. published 《Development of an optimized process for the preparation of 1-Benzylazetidin-3-ol: an industrially important intermediate for substituted azetidine》.Organic Process Research & Development published the findings.Name: Azetidin-3-ol hydrochloride The information in the text is summarized as follows:
A thoroughly optimized and robust process for the synthesis of 1-benzylazetidin-3-ol has been emphasized. 1-Benzylazetidin-3-ol I, has been utilized as a starting material in the com. synthesis of azetidin-3-ol hydrochloride. Synthesis of azetidin-3-ol hydrochloride involves the usage of very low cost and com. available starting material (benzylamine) and with reduced formation of di(3-chloro-2-hydroxypropyl) benzylamine significantly resulting in an economical process that allows the effective production of 1-benzyl azetidin-3-ol as well as azetidin-3-ol hydrochloride. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Name: Azetidin-3-ol hydrochloride)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Name: Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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