Kishore, M.; VijayaKumar, B.; NarasimhaReddy, Y. published the artcile< Formulation and evaluation of olsalazine sodium enteric coated tablets in ulcerative colitis>, Computed Properties of 6054-98-4, the main research area is olsalazine sodium enteric tablet coating ulcerative colitis.
Aim: To formulate and evaluate the fabricated olsalazine sodium enteric coated tablets in ulcerative colitis and also compare the In-vitro dissolution profile of optimized Olsalazine sodium enteric coated tablets in the presence of β- glycosidase at targeted colonic region. Materials: Olsalazine sodium, obtained as a gift sample from Aurbindo Pharmaceuticals Hyderabad, Telangana, and India. Et cellulose, Chitosan, PVP K30, Magnesium stearate, Lactose, Eudragit S-100, Acetone, Tri-Et citrate was used as a plasticizer etc. All the above polymers and excipients are obtained from S.D Fine Chems., Mumbai. Conclusion: The present study was fabricated to observe the drug release of Olsalazine sodium enteric coated tablets at targeted site specific colon region. These tablets were formulated from F1-F8 by selecting time dependent and release retard biodegrable polymers such as Et cellulose-chitosan composite by combining with different concentrations by wet granulation. This composite was included in this study to control the solubility of premature drug release in gastrointestinal fluid and in this regard, the above formulation F6 was optimized and coated with Eudragit-S 100 as enteric polymer as to retard the drug release at specified site colon by changing suitable concentration as like 1, 3, 5, and7 %. From which F6 containing 5% Eudragit-S 100 was shown only 75.6 % drug release in 24 h and also it was compared with dissolution medium containing β-glycosidase. In which enzymic condition the above formulation enhanced the drug release i.e, 98.3% was found in 24 h. Finally the current study was contributed to evaluated all pre, post compressional parameters of optimized formulation with various release kinetic mechanism such as zero order, first order, higuchi plot and peppas mayer equations studies.
International Journal of Pharmacy and Technology published new progress about Compressibility. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Computed Properties of 6054-98-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts