Kim, Joseph Byung-Kyu; Mackeyev, Yuri; Raghuram, Subhiksha; Cho, Sang Hyun; Krishnan, Sunil published an article in 2021. The article was titled 《Synthesis and characterization of gadolinium-decorated [60]fullerene for tumor imaging and radiation sensitization》, and you may find the article in International Journal of Radiation Biology.Product Details of 534-03-2 The information in the text is summarized as follows:
The excellent contrast of high at. number (Z) elements compared to soft tissues has advanced their use as contrast agents for computed tomog. imaging and as potential radiation sensitizers. We evaluated whether gadolinium (Gd) could serve as such a theranostic agent for high-resolution magnetic resonance imaging (MRI) due to its paramagnetic properties and radiosensitization due to its high Z. To improve the relaxivity of Gd, we coupled it to [60]fullerene, an elemental carbon allotropic nanoparticle that seamlessly traverses physiol. barriers . By adding serinol, an aliphatic alc. derived from amino acid serine, we turned [60]fullerene, which is otherwise insoluble in water, into a highly water-soluble derivative and decorated it externally with a payload of chelated gadolinium ions. When [60]fullerene was functionalized in this manner with two gadolinium ions (Gd2C60), it displayed considerably higher T1 relaxivity at 4.7 T than the com. used MRI contrast agent, Magnevist, (18.2 mM-1s-1 vs. 4.7 mM-1s-1). Attempts to increase this even further via decoration of [60]fullerene with 12 gadolinium ions was unsuccessful due to a poor water solubility However, the current formulation of Gd2C60 did not result in any appreciable radiosensitization. Our results show a successful generation of a novel contrast agent via decoration of fullerene with two chelated Gd ions. Though this formulation was not successful in generating radiosensitization, other chem. modifications can be further explored to increase radiosensitization potential. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 534-03-2
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