Imperio, Daniela; Muz, Barbara; Azab, Abdel Kareem; Fallarini, Silvia; Lombardi, Grazia; Panza, Luigi published the artcile< A Short and Convenient Synthesis of closo-Dodecaborate Sugar Conjugates>, Application of C12H20O6, the main research area is boron neutron capture therapy dodecaborate sugar conjugate.
Dodecaborate anions represent a suitable boron source for boron neutron capture therapy (BNCT). Sugar derivatives of dodecaborate have been prepared through the ring-opening reaction of cyclic oxonium ions by alkoxide nucleophiles. According to this general approach, a convenient and short synthesis of three derivatives of dodecaborate-sugar conjugates is herein reported. Glucose, galactose and fructose have been chosen for their expected preferential uptake by tumor cells compared to healthy cells. The free hydroxyl group of isopropylidene protected sugars was exploited as nucleophile to open a dodecaborate cyclic oxonium salt, giving products containing a spacer between the sugar and the boron cluster. Deprotection of the sugar moiety in acidic conditions gave the desired compounds in excellent yield.
European Journal of Organic Chemistry published new progress about Antitumor agents. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application of C12H20O6.
Referemce:
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Alcohols – Chemistry LibreTexts