Heindel, Daniel W.; Koppolu, Sujeethraj; Zhang, Yue; Kasper, Brian; Meche, Lawrence; Vaiana, Christopher A.; Bissel, Stephanie J.; Carter, Chalise E.; Kelvin, Alyson A.; Elaish, Mohamed; Lopez-Orozco, Joaquin; Zhang, Bin; Zhou, Bin; Chou, Tsui-Wen; Lashua, Lauren; Hobman, Tom C.; Ross, Ted M.; Ghedin, Elodie; Mahal, Lara K. published the artcile< Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity>, Reference of 3458-28-4, the main research area is mannose lectin MBL2 Influenza virus infection glycomic; MBL2; lectin array; lectin microarray; mannan binding lectin; mannose binding lectin.
Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ∼290,000 to 645,000 deaths annually worldwide. The mol. mechanisms underlying these disparate outcomes are currently unknown. Glycosylation within the human host plays a critical role in influenza virus biol. However, the impact these modifications have on the severity of influenza disease has not been examined Herein, we profile the glycomic host responses to influenza virus infection as a function of disease severity using a ferret model and our lectin microarray technol. We identify the glycan epitope high mannose as a marker of influenza virus-induced pathogenesis and severity of disease outcome. Induction of high mannose is dependent upon the unfolded protein response (UPR) pathway, a pathway previously shown to associate with lung damage and severity of influenza virus infection. Also, the mannan-binding lectin (MBL2), an innate immune lectin that neg. impacts influenza outcomes, recognizes influenza virus-infected cells in a high mannose-dependent manner. Together, our data argue that the high mannose motif is an infection-associated mol. pattern on host cells that may guide immune responses leading to the concomitant damage associated with severity.
Proceedings of the National Academy of Sciences of the United States of America published new progress about Epitopes (glycan). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts