Hamdi, Naceur.; Slimani, Ichraf; Mansour, Lamjed; Alresheedi, Faisal; Ozdemir, Ismail; Gurbuz, Nevin published the artcile< Rhodium(I) complexes with N-heterocyclic carbene ligands: synthesis, biological properties and catalytic activity in the hydrosilylation of aromatic ketones>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is rhodium NHC benzimidazolylidene cyclooctadiene complex preparation antibacterial antitumor agent; ketone hydrosilylation catalyst rhodium NHC benzimidazolylidene cyclooctadiene complex; crystal mol structure buried volume rhodium NHC benzimidazolylidene complex.
New rhodium(I) N-heterocyclic carbene (NHC) complexes were synthesized in good yields by the reactions of rhodium dimer [Rh(OMe)(cycloocta-1,5-diene:COD)]2 with benzimidazolium salts in THF. All the complexes were characterized by IR, 1H-NMR, and 13C-NMR spectroscopy, DART-TOF mass spectrometry and elemental anal. All complexes were used as catalysts in the hydrosilylation of acetophenone derivatives with triethylsilane at 80°C for 1 h. These Rh(I) NHC showed good catalytic performance for the hydrosilylation of acetophenone derivatives by using 1 mol % of the rhodium complexes. In addition the new rhodium(I) NHC complexes were tested against MCF7 and MDA-MB-231 cancer cells, Micrococcus luteus LB 14110, Listeria monocytogenes ATCC 19117, Salmonella Typhimurium ATCC 14028, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa and Candida albicans microorganisms. The synthesized rhodium(I) NHC complex was found the most active against MCF7 cancer cells (half-growth inhibition concentration (IC50) = 0.3μg mL-1), as well as the most potent antimicrobial against L. monocytogenes ATCC 19117 (inhibition zone (IZ) = 29 mm). Moreover, the antioxidant activity determination of these complexes was studied with the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) and compared with gallic acid and butylated hydroxytoluene.
Journal of Coordination Chemistry published new progress about Antibacterial agents. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.
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