Gunda, Venugopal; Genaro-Mattos, Thiago C.; Kaushal, Jyoti B.; Chirravuri-Venkata, Ramakanth; Natarajan, Gopalakrishnan; Mallya, Kavita; Grandgenett, Paul M.; Mirnics, Karoly; Batra, Surinder K.; Korade, Zeljka; Rachagani, Satyanarayana published the artcile< Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma>, Application In Synthesis of 434-16-2, the main research area is cholesterol metabolism pancreatic ductal adenocarcinoma; Dhcr24; Dhcr7; PDAC (pancreatic ductal adenocarcinoma); free cholesterol; sterol analysis.
Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clin. specimens and preclin. PC models. Cholesterol is one of the critical metabolites supporting PC, synthesized or acquired by PC cells. Nevertheless, the significance of the de novo cholesterol synthesis pathway has been controversial in PC, indicating the need to reassess this pathway in PC. We utilized preclin. models and clin. specimens of PC patients and cell lines and utilized mass spectrometry-based sterol anal. Further, we also performed in silico anal. to corroborate the significance of de novo cholesterol synthesis pathway in PC. Our results demonstrated alteration in free sterol levels, including free cholesterol, across in vitro, in vivo, and clin. specimens of PC. Especially, our sterol analyses established consistent alterations in free cholesterol across the different PC models. Overall, this study demonstrates the significance and consistency in deviation of cholesterol synthesis pathway in PC while showing the aberrations in sterol metabolite intermediates and the related genes using preclin. models, in silico platforms, and the clin. specimens.
Metabolites published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (DHCR24). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application In Synthesis of 434-16-2.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts