《Palladium-Catalyzed Aminocarbonylation Reaction to Access 1,2,3-Triazole-5-carboxamides Using Dimethyl Carbonate as Sustainable Solvent》 was written by de Albuquerque, Danilo Yano; de Moraes, Juliana R.; Schwab, Ricardo S.. Name: 4-Aminobutan-1-olThis research focused ontriazole carboxamide preparation; amine iodotriazole formic acid carbonylative coupling. The article conveys some information:
A simple and direct palladium-catalyzed aminocarbonylation of 5-iodo-1,2,3-triazoles backbone for the incorporation of an amide functional group was presented. The approach was based on the palladium catalyzed carbonylative coupling reaction of iodo-triazole with different amines employing formic acid and sulfuric acid as CO source (Morgan’s reaction) to provide the 1,2,3-triazole-5-carboxamides I [R = Bn, 4-OMeC6H4, C10H21, etc.; R1 = H, n-Bu, Ph, etc.] in good to excellent yields. The important features of this methodol. included short reaction time, high yields, the use of di-Me carbonate as a sustainable solvent and the use of efficient alternative source of carbon monoxide, avoiding pressurized cylinder. The methodol. described herein for the synthesis of 1,4,5-trisubstituted 1,2,3-triazole-5-carboxamides I, could offer an alternative path for functionalization of other heterocycles. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts