《An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer’s disease mice》 was written by Dang, Yijing; Wang, Fengyang; Li, Lingling; Lai, Yi; Xu, Zhiai; Xiong, Zhi; Zhang, Ao; Tian, Yang; Ding, Chunyong; Zhang, Wen. Category: alcohols-buliding-blocks And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:
Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, the authors disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by using a thiadiazole-fused o-phenylenediamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Category: alcohols-buliding-blocks)
3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts