Dang, Le Hang; Doan, Phuong; Nhi, Tran Thi Yen; Nguyen, Dinh Trung; Nguyen, Bich Tram; Nguyen, Thi Phuong; Tran, Ngoc Quyen published an article in 2021. The article was titled 《Multifunctional injectable pluronic-cystamine-alginate-based hydrogel as a novel cellular delivery system towards tissue regeneration》, and you may find the article in International Journal of Biological Macromolecules.Reference of 3-Aminopropan-1-ol The information in the text is summarized as follows:
This paper presents a new thermal sensitive hydrogel system based on cystamine-functionalised sodium alginate-g-pluronic F127 (ACP). The introduction of cystamine to the alginate backbone not only creates a covalent bond with pluronic F127 but also provides intrinsic anti-bacterial activity for the resultant hydrogel. The amount of water uptake inside the hydrogel remained ∼200% for 6 days and the degradation was completed in 12 days in physiol. media. The ACP copolymer solution could form a hydrogel at body temperature (∼37 °C) and could return to the solution phase if the temperature decreased below 25°C. Fibroblast encapsulated in situ in the ACP hydrogel maintained their viability (≥90% based on the live/dead assay) for 7 days, demonstrating the good biocompatibility of the ACP hydrogel for long-term cell cultivation. In addition, three-dimensional (3D) culture showed that fibroblast attached to the hydrogels and successfully mimicked the porous structure of the ACP hydrogel after 5 days of culture. Fibroblast cells could migrate from the cell-ACP clusters and form a confluent cell layer on the surface of the culture dish. Altogether, the obtained results indicate that the thermal-responsive ACP hydrogel synthesized in this study may serve as a cellular delivery platform for diverse tissue engineering applications. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of 3-Aminopropan-1-ol
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