In 2022,Boukherrouba, Emeline; Larosa, Camille; Nguyen, Kim-Anh; Caburet, Jeremy; Lunven, Laurent; Bonnet, Hugues; Fortune, Antoine; Boumendjel, Ahcene; Boucherle, Benjamin; Chierici, Sabine; Peuchmaur, Marine published an article in European Journal of Medicinal Chemistry. The title of the article was 《Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers》.Application of 26153-38-8 The author mentioned the following in the article:
Tauopathies, such as Alzheimer′s disease, have been the subject of several hypotheses regarding the way to treat them. Hyperphosphorylation of tau protein leading to its aggregation is widely recognized as a key step in the development of these diseases resulting in neuronal dysfunction. The AcPHF6 model of tau that includes the shorter critical fragment involved in the protein aggregation was used in vitro to identify new potential inhibitors. Following a previous study on aurone derivatives, we herein compare this polyphenol family to a very close one, the benzylidene-2,3-dihydro-1H-inden-1-one (also named indanone). The structure activity relationship studies bring to light the importance of the hydroxylation pattern in both series: the more hydroxylated, the more active. In addition, the three-dimensional shape of the mols. is involved in their interaction mode with their target, thus defining their role either as inhibitors of fiber elongation or as fiber-binding mols. Indanone 13a was identified as a promising inhibitor: its activity was confirmed by CD and at. force microscopy studies. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8) was used in this study.
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Application of 26153-38-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts