Aumala, Ville; Mollerup, Filip; Jurak, Edita; Blume, Fabian; Karppi, Johanna; Koistinen, Antti E.; Schuiten, Eva; Voss, Moritz; Bornscheuer, Uwe; Deska, Jan; Master, Emma R. published the artcile< Biocatalytic production of amino carbohydrates through oxidoreductase and transaminase cascades>, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is amino carboxydrate production biocatalysis oxidoreductase transaminase enzyme cascade; amination; biocatalysis; carbohydrates; domino reactions; enzymes.
Plant-derived carbohydrates are an abundant renewable resource. Transformation of carbohydrates into new products, including amine-functionalized building blocks for biomaterials applications, can lower reliance on fossil resources. Herein, biocatalytic production routes to amino carbohydrates, including oligosaccharides, are demonstrated. In each case, two-step biocatalysis was performed to functionalize D-galactose-containing carbohydrates by employing the galactose oxidase from Fusarium graminearum or a pyranose dehydrogenase from Agaricus bisporus followed by the ω-transaminase from Chromobacterium violaceum (Cvi-ω-TA). Formation of 6-amino-6-deoxy-D-galactose, 2-amino-2-deoxy-D-galactose, and 2-amino-2-deoxy-6-aldo-D-galactose was confirmed by mass spectrometry. The activity of Cvi-ω-TA was highest towards 6-aldo-D-galactose, for which the highest yield of 6-amino-6-deoxy-D-galactose (67%) was achieved in reactions permitting simultaneous oxidation of D-galactose and transamination of the resulting 6-aldo-D-galactose.
ChemSusChem published new progress about Agaricus bisporus (pyranose dehydrogenase from). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts