《Nanocomposites of ionic copolymer integrating Gd-containing polyoxometalate as a multiple platform for enhanced MRI and pH-response chemotherapy》 was written by Zhou, Tingting; Wan, Guofeng; Li, Bao; Wu, Lixin. Synthetic Route of C3H7BrO And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2020. The article conveys some information:
This article describes the fabrication of nanosized paramagnetic drug carriers via the assembly of a pH-responsive hydrophilic block copolymer poly(polyethylene glycol Me ether methacrylate)-b-poly(methacrylic acid-co-trimethyl ammonium bromide Pr methacrylate) (PPMT) and polyoxometalate K13[Gd(β2-SiW11O39)2] (GdSiW11) through electrostatic interaction. Owing to the hydrophilicity, large mol. weight, and high content of the GdSiW11 cluster bearing in the nanocomposites, the organic-inorganic nanocomposite exhibited an impressive longitudinal relaxivity as a contrast agent for magnetic resonance imaging (MRI). The surplus neg. charges from the polyoxometalate cluster in the polymer nanocomposites facilitated the capture of the anti-tumor drug doxorubicin (DOX). The DOX-loaded nanocomposites were stable under the physiol. environment, whereas a responsive release of DOX was achieved at pH values similar to the tumor microenvironment due to the regulation of the polyoxometalate and carboxyl groups. The DOX-loaded PPMT2-GdSiW11 nanocomposites were observed to enrich effectively at tumor sites through MRI after i.v. injection. Furthermore, the DOX-loaded composites manifested enhanced in vivo anti-tumor therapeutic efficacy and sustainable circulation time of more than 5 h, which were favorable for imaging measurement. With the advantages of the designed composite system, the present experiments propose a strategy for developing a new multiple imaging-drug delivery-local therapy platform for synergistic diagnosis and therapy. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Synthetic Route of C3H7BrO)
3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Synthetic Route of C3H7BrO
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