Zhang, Yueteng; Ji, Peng; Gao, Feng; Huang, He; Zeng, Fanxun; Wang, Wei published the artcile< Photoredox Asymmetric Nucleophilic Dearomatization of Indoles with Neutral Radicals>, Electric Literature of 4064-06-6, the main research area is chiral indolines preparation photochem regioselective diastereoselective chemoselective; indole tertiary amine neutral radical photoredox asym dearomatization.
The dearomatization of indoles represents the most efficient approach for accessing highly valued indolines. The inherent nucleophilic reactivity of indoles has dictated indole dearomatization development in both 1e- and 2e- processes. However, the dearomatization of electron-deficient indoles has been challenging. Herein, authors introduce a conceptually distinct photoredox-mediated Giese-type transformation strategy, which is generally used for the conjugate addition of radicals to simple α, β-unsaturated systems, for chemoselectively breaking C=C bonds embedded in the aromatic structure. Moreover, highly diastereoselective addition of challenging neutral radicals has been achieved by Oppolzer camphorsultam chiral auxiliary. Structurally diverse amine-functionalized chiral indolines carrying distinct functional and stereochem. diversity are produced from a wide array of amines as radical precursors. Furthermore, the mild, powerful manifold is capable of the late-stage modification of complex natural products and pharmaceuticals. DFT studies are performed to elucidate the observed stereochem. outcomes.
ACS Catalysis published new progress about C-C bond formation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Electric Literature of 4064-06-6.
Referemce:
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