In 2022,Wilhelmsen, Christopher A.; Zhang, Xuntong; Myhill, Jesse A.; Morken, James P. published an article in Angewandte Chemie, International Edition. The title of the article was 《Enantioselective Synthesis of Tertiary β-Boryl Amides by Conjunctive Cross-Coupling of Alkenyl Boronates and Carbamoyl Chlorides》.COA of Formula: C13H26B2O4 The author mentioned the following in the article:
Synthesis of versatile β tert-boryl amides is accomplished by conjunctive cross-coupling of α-substituted alkenyl boron “”ate”” complexes and carbamoyl chloride electrophiles. This reaction can be accomplished in an enantioselective fashion using a palladium catalyst in combination with MandyPhos. The addition of water results in enhanced chemoselectivity for the conjunctive coupling product relative to the Suzuki-Miyaura cross-coupling product. Transformations of the reaction products were examined as well as application to the synthesis of (+)-adalinine. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9COA of Formula: C13H26B2O4)
Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.COA of Formula: C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.
Referemce:
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