In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Toda, Yasunori; Tanaka, Shoya; Gomyou, Shuto; Kikuchi, Ayaka; Suga, Hiroyuki. Application In Synthesis of (R)-Oxiran-2-ylmethanol. The article was titled 《4-Hydroxymethyl-substituted oxazolidinones synthesis by tetraarylphosphonium salt-catalyzed reactions of glycidols with isocyanates》. The information in the text is summarized as follows:
Preparation of 4-hydroxymethyl-substituted oxazolidinones including optically active ones, in which tetraarylphosphonium salts catalyze the reaction of glycidol with isocyanates effectively, is described. The neutral catalysis facilitates glycidol addition to isocyanates followed by intramol. cyclization. Mechanistic studies suggest that hydrogen-bonding interactions with the catalyst play an important role in the reaction progress. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application In Synthesis of (R)-Oxiran-2-ylmethanol)
(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application In Synthesis of (R)-Oxiran-2-ylmethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts