《Synthesis and biological activity of some new- 4-(4-(1H-imidazol-1-yl)phenyl)-6-phenylpyrimidine-2(1H)-thione derivatives》 was written by Tabassum, Zeaba; Nizami, Syed Azhar; Gurumurthy, M.. SDS of cas: 100-83-4 And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2020. The article conveys some information:
Imidazole on reaction with 1-(4-chlorophenyl) ethanone in the presence of absolute ethanol gave 1-(4-(-imidazol-1-yl) phenyl) ethanone, condensation of this with various benzaldehydes offered 1-(4-(Imidazol-1-yl)phenyl) -3-phenylprop-2-en-1-ones I [R = Ph, 3-hdroxyphenyl, 4-methoxyphenyl, 2-hydroxy-3-methoxy Ph, 3-nitrophenyl], which on cyclization with thiourea yielded 4-(4-(1H-imidazol-1-yl)phenyl)-6-phenylpyrimidine-2(1H)-thione II. The structures of newly synthesized compounds II were confirmed by FTIR, 1HNMR and mass spectral data. Compounds II were screened for in-vitro anti-inflammatory activity by inhibition of albumin denaturation technique and antiproteinase action. All the synthesized substituted thiopyrimidine compounds II showed moderate to good anti-inflammatory activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4
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