Patra, Kamaless; Laskar, Roshayed Ali; Nath, Anubhav; Bera, Jitendra K. published the artcile< A Protic Mn(I) Complex Based on a Naphthyridine-N-oxide Scaffold: Protonation/Deprotonation Studies and Catalytic Applications for Alkylation of Ketones>, Application of C7H9NO, the main research area is cyclometalated manganese naphthyridine oxide carbonyl complex preparation alkylation catalyst; crystal structure cyclometalated manganese naphthyridine oxide carbonyl complex; mol structure cyclometalated manganese naphthyridine oxide carbonyl complex; alkylation ketone primary alc manganese naphthyridine oxide catalyst.
A Mn(I) complex (1) bearing a proton responsive hydroxy unit on 1,8-naphthyridine-N-oxide scaffold (L1H) was synthesized. The mol. structure of 1 revealed the lactim form of the ligand. The corresponding deprotonated lactam complexes [18-C-6-K·2] and 3 were prepared and structurally characterized. The acid-base equilibrium between the lactim and lactam forms was studied by 1H NMR and UV-visible spectra. The catalytic efficiency of 1 was evaluated by performing α-alkylation reaction of ketones with primary alcs. The scope of the α-alkylation reaction is broad in terms of both ketones and alcs. The efficacy of the protic catalyst is demonstrated in the alkylation of the bioactive steroids progesterone and pregnenolone. A controlled catalyst [Mn(L2)(CO)3Br] (4), which is structurally similar to 1 but devoid of the proton responsive hydroxy unit, shows significantly reduced catalytic efficiency validating the crucial role of the hydroxy functionality in 1. Kinetic study, control reactions, and D labeling experiments were conducted to gain mechanistic insights.
Organometallics published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts