《RP-HPLC separation and ESI-MS, 1H, and 13C NMR characterization of forced degradants including process related impurities of carisbamate: Method development and validation》 was written by Nageswara Rao, Ramisetti; Ramakrishna, Kuntamukkala; Sravan, Bompelli; Santhakumar, Kondapalli. Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol And the article was included in Journal of Pharmaceutical and Biomedical Analysis on April 15 ,2013. The article conveys some information:
A stability indicating reversed phase HPLC method was developed and validated for determination of process related impurities and forced degradants of carisbamate (CRS) in bulk drugs. Carisbamate when subjected to acid/base hydrolysis, H2O2 oxidation, photolysis and thermal stress significant degradation was observed during acid/base hydrolysis and the degradants were isolated and characterized by ESI-MS, 1H and 13C NMR. MS/MS and 2D-NMR (COSY and HSQC) studies revealed the possible isomerization of CRS under stress conditions. The optimum separation was accomplished on Agilent XDB C18 column (150 mm × 4.6 mm; 5 μm) using 0.02 M KH2PO4 (pH = 3.5) and CH3CN as a mobile phase in a gradient elution mode at a flow rate of 1.0 mL/min. The eluents were monitored by PDA detector at 211 nm and quantitation limits were obtained in the range of 0.1-0.3 μg/mL for CRS, degradants and other impurities. The LC method was validated with respect to accuracy, precision, linearity, robustness and limits of detection and quantification as per ICH guidelines. In addition to this study using (1S)-1-(2-chlorophenyl)ethane-1,2-diol, there are many other studies that have used (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol) was used in this study.
(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts