In 2017,Maxwell, Brad D. published 《The syntheses of [13C6] and [phenyl-14C(U)]BMS-816336, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1, for type 2 diabetes》.Journal of Labelled Compounds and Radiopharmaceuticals published the findings.HPLC of Formula: 18621-18-6 The information in the text is summarized as follows:
Type 2 diabetes is a significant worldwide health problem. To support the development of BMS-816336 as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 for type 2 diabetes, the synthesis of carbon-14 labeled material was required for use in metabolic profiling. [Phenyl-14C(U)]BMS-816336 (A) was synthesized in 8 steps and 22% radiochem. yield from com. available [14C(U)]bromobenzene. The radiochem. purity of A was 100% having a specific activity of 84.4 μCi/mg or 28.8 mCi/mmol for a total of 8.9 mCi. It was also necessary to synthesize [13C6]BMS-816336 (B) for use as a liquid chromatog./mass spectrometry standard B was also prepared in 8 labeled steps in 26% yield from [13C6]bromobenzene. In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts