Mattocks, A. R.; Legg, R. F. published the artcile< Antimitotic activity of dehydroretronecine, a pyrrolizidine alkaloid metabolite, and some analogous compounds, in a rat liver parenchymal cell line>, Reference of 52160-51-7, the main research area is pyrrolizidine alkaloid metabolite antimitosis; pyrrolic alc antimitosis liver.
The actions of 13 pyrrolic alcs. with similar chem. properties were tested on cultured liver cells. Dehydroretronecine (I) [23107-12-2] and dehydrosupinidine (II) [27628-47-3] were putative metabolites of hepatotoxic pyrrolizidine alkaloids and the remainder were synthetic. All were either mono- or bifunctional alkylating agents. Groups of cells were exposed to the compounds, and later stimulated to divide by changing the medium, then fixed, stained, and the proportions of cells in mitosis counted and compared with those in similarly treated control cells. Eleven compounds partially or completely inhibited cell division at 10-4 M. Bifunctional compounds, including I and 2,3-bis(hydroxymethyl)-1-methylpyrrole [53365-77-8], had the highest antimitotic activity coupled with the lowest cytotoxicity. The least chem. reactive compound, 3-(hydroxymethyl)-1-methylpyrrole [68384-83-8], was neither antimitotic nor cytotoxic, whereas the monofunctional alkylating agents with highest reactivity, such as 3-(hydroxymethyl)-1,2-dimethylpyrrole [68384-74-7] were the most toxic to the cells. The mitotic block occurred at a postsynthetic stage of the cell cycle, and affected cells could grow to a giant size.
Chemico-Biological Interactions published new progress about Alkylating agents. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Reference of 52160-51-7.
Referemce:
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