Mal′shakova, Marina V.; Velegzhaninov, Ilya O.; Rasova, Elena E.; Belykh, Dmitry V. published the artcile< Novel chlorophyll a derivatives with ester-linked galactose fragments for photodynamic therapy and fluorescence diagnostics of cancer>, Reference of 4064-06-6, the main research area is chlorophyll galactose fragment photodynamic therapy fluorescence diagnostis cancer.
In the present work, a number of chlorophyll a derivatives were synthesized with galactose fragments with an ester bond between macrocycle and carbohydrate fragments. It showed that synthesized compounds fluoresce intensely inside HeLa cells, which enable these compounds to be considered as potential diagnostic agents and indicates their ability to remain in the cell in an unassocd. photoactive state – a necessary condition for the realization of a photodynamic action. It was determined that while all conjugates had comparable photoinduced toxicities, the conjugate with phorbin macrocycle fragment had a much lower dark toxicity, which corresponds to the trends noted earlier. In terms of a therapeutic window, conjugate significantly exceeds similar derivatives of chlorin e6 and is the most promising for further research.
Journal of Porphyrins and Phthalocyanines published new progress about Antitumor agents. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Reference of 4064-06-6.
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