Category: alcohols-buliding-blocksIn 2019 ,《Rapid Solution-Phase Hydrogen/Deuterium Exchange for Metabolite Compound Identification》 was published in Journal of the American Society for Mass Spectrometry. The article was written by Majuta, Sandra N.; Li, Chong; Jayasundara, Kinkini; Kiani Karanji, Ahmad; Attanayake, Kushani; Ranganathan, Nandhini; Li, Peng; Valentine, Stephen J.. The article contains the following contents:
Rapid, solution-phase hydrogen/deuterium exchange (HDX) coupled with mass spectrometry (MS) is demonstrated as a means for distinguishing small-mol. metabolites. HDX is achieved using capillary vibrating sharp-edge spray ionization (cVSSI) to allow sufficient time for reagent mixing and exchange in micrometer-sized droplets. Different compounds are observed to incorporate deuterium with varying efficiencies resulting in unique isotopic patterns as revealed in the MS spectra. Using linear regression techniques, parameters representing contribution to exchange by different hydrogen types can be computed. In this proof-of-concept study, the exchange parameters are shown to be useful in the retrodiction of the amount of deuterium incorporated within different compounds On average, the exchange parameters retrodict the exchange level with ∼ 2.2-fold greater accuracy than treating all exchangeable hydrogens equally. The parameters can be used to produce hypothetical isotopic distributions that agree (± 16% RMSD) with exptl. measurements. These initial studies are discussed in light of their potential value for identifying challenging metabolite species. [Figure not available: see fulltext.]. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts