《HARC as an open-shell strategy to bypass oxidative addition in Ullmann-Goldberg couplings》 was published in Proceedings of the National Academy of Sciences of the United States of America in 2020. These research results belong to Lavagnino, Marissa N.; Liang, Tao; MacMillan, David W. C.. HPLC of Formula: 7748-36-9 The article mentions the following:
Herein, an alternative aryl halide activation strategy, in which the critical oxidative addition (OA) mechanism was replaced by a halogen abstraction-radical capture (HARC) sequence that allowed the generation of the Cu(III)-aryl intermediate albeit via a photoredox pathway was presented. This alternative mechanistic paradigm decoupled the bond-breaking and bond-forming steps of the catalytic cycle to enable the use of many previously inert aryl bromides. Overall, this mechanism allowed access to both traditional C-N adducts at room temperature as well as a large range of previously inaccessible Ullmann-Goldberg coupling products including sterically demanding ortho-substituted heteroarenes, e.g., I. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9
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