Related Products of 100-55-0In 2021 ,《A predictive model for additions to N-alkyl pyridiniums》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Knight, Brian J.; Tolchin, Zachary A.; Smith, Joel M.. The article conveys some information:
Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochem. outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Addnl., the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity. In the experiment, the researchers used many compounds, for example, 3-Pyridinemethanol(cas: 100-55-0Related Products of 100-55-0)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 100-55-0
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