Application of 57044-25-4On May 15, 2019 ,《Photo-control of cancer cell growth by benzodiazo N-substituted pyrrole derivatives》 appeared in Journal of Photochemistry and Photobiology, A: Chemistry. The author of the article were Imperatore, Concetta; Scuotto, Maria; Valadan, Mohammadhassan; Rivieccio, Elisa; Saide, Assunta; Russo, Annapina; Altucci, Carlo; Menna, Marialuisa; Ramunno, Anna; Mayol, Luciano; Russo, Giulia; Varra, Michela. The article conveys some information:
In order to expand the class of diazocompounds able to act as photo-activable microtubule inhibitors the potential of azo-heteroarenes has been explored. In this paper we focus on the synthesis, phys. properties and biol. effects of Me rac-2-(2-((E)-(4-((R)-2,3-dihydroxypropoxy)phenyl) diazenyl)-1H-pyrrol-1-yl)-3-hydroxypropanoate (1a) and Me rac-2-(2-((E)-(4-((S)-2,3-dihydroxypropoxy)phenyl) diazenyl)-1H-pyrrol-1-yl)-3-hydroxypropanoate (1b). Preliminary biol. studies on the HCT-116 p53-/- cancer cell line have shown that the weak antiproliferative action of the trans isomers of these mols., especially of 1a, is enhanced upon LED light irradiation at 435 nm. On A375 cells the mols. have not shown any effect on cell viability either in the dark or under irradiation Moreover, the two diastereomeric components of 1a as pure stereomers have been synthesized and characterized for their chem.-phys. properties. Interestingly, upon irradiation, 1a has shown an antiproliferative activity on the HCT-116 p53-/- cells greater than that of the pure stereomers, 1RR and 1RS. Tubulin polymerization assay has also demonstrated that 1a, 1RR and 1RS inhibit tubulin aggregation mostly after exposure of the samples to LED light irradiation The experimental part of the paper was very detailed, including the reaction process of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application of 57044-25-4)
(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application of 57044-25-4
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