《Stability indicating rp-hplc method for combination of ambroxol hydrochloride and levofloxacin hemihydrate in pharmaceutical formulation》 was published in International Journal of Pharmaceutical Sciences and Research in 2019. These research results belong to Goswami, J. A.; Shah, N. J.. Electric Literature of C13H19Br2ClN2O The article mentions the following:
Ambroxol hydrochloride (AMB) and Levofloxacin hemihydrate (LVF) in combination were separated using Reverse-Phase – High-Performance Liquid Chromatog. (RP-HPLC) method. Mobile phase acetonitrile and 0.05 M potassium di-hydrogen orthophosphate buffer (pH 7.0 adjusted with sodium hydroxide solution) (50: 50, volume/volume) was selected for this chromatog. method. The separation was achieved in Zorbax Eclipse XDB -C18 column with (250 × 4.5 mm i.d), 5μm particle size with a flow rate of 1.0 mL/min. At 248 nm wavelength, 10μl of 60μg/mL Ambroxol hydrochloride and 400μg/mL Levofloxacin hemihydrate (LVF) was injected for 15 min runtime, and an individual peak was obtained for LVF at retention time 2.61 min and for AMB at retention time 7.69 min. Linearity was achieved for Ambroxol hydrochloride in the range of 48 mcg/mL to 72 mcg/mL and Levofloxacin hemihydrate in the range of 320 mcg/mL to 480 mcg/mL. For stress degradation, AMB and LVF were subjected to acid hydrolysis, base hydrolysis, thermal degradation, UV light degradation, oxidation and analyzed with this chromatog. method. The results obtained with this method are useful for assay of this pharmaceutical formulation; hence this method can be used in the pharmaceutical industry.trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Electric Literature of C13H19Br2ClN2O) was used in this study.
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Electric Literature of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts