Gampa, Muralimohan; Padmaja, Pannala; Aravind, Seema; Reddy, Pedavenkatagari Narayana published an article in 2021. The article was titled 《An efficient one-pot synthesis of indolyl-4H-chromene derivatives》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).Category: alcohols-buliding-blocks The information in the text is summarized as follows:
A new one-pot three-component reaction for the synthesis of indolyl-4H-chromene derivatives I (R1 = H, 6-Cl, 6-Br, 6,8-(Cl)2; R2 = 2-Me, 5-OH, 6-Br, etc.; R3 = CH, N) has been developed. The synthesis was achieved by reacting salicylaldehydes 1-CHO-2-OHC6H3R1 (R1 = H, 5-Cl, 5-Br, 3,5-Cl2), (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine, and indoles II in the absence of solvent using triethylamine as a catalyst. The final products I were isolated by precipitation after the addition of ethanol to the reaction mixture This transformation involves the formation of indole-substituted chromene ring by creation of two C-C bonds and one C-O bond in a single synthetic operation. This rapid one-pot reaction does not require chromatog. purification and provides the indolyl-4H-chromene derivatives I in good yields. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts