Chandrashekhar, Vishwas G.; Baumann, Wolfgang; Beller, Matthias; Jagadeesh, Rajenahally V. published an article in 2022. The article was titled 《Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis》, and you may find the article in Science (Washington, DC, United States).Synthetic Route of C6H13NO The information in the text is summarized as follows:
A homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic nitriles with primary and secondary amines or ammonia to give amines was reported. This general hydrogenation protocol was showcased by straightforward and highly selective synthesis of >230 functionalized and structurally diverse amines including pharmaceutically relevant and chiral products, as well as 15N-isotope labeling applications.trans-4-Aminocyclohexanol(cas: 27489-62-9Synthetic Route of C6H13NO) was used in this study.
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C6H13NO
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