Abdullah, Orva; Usman Minhas, Muhammad; Ahmad, Mahmood; Ahmad, Sarfaraz; Ahmad, Aousaf published the artcile< Synthesis of hydrogels for combinatorial delivery of 5-fluorouracil and leucovorin calcium in colon cancer: optimization, in vitro characterization and its toxicological evaluation>, Computed Properties of 1492-18-8, the main research area is leucovorin calcium 5fluorouracil drug delivery hydrogel colon cancer.
Chem. crosslinking of monomers methacrylic acid (MAA) and itaconic acid (IA) through ethylene glycol dimethacrylate (EGDMA) was carried out for synthesizing robust hydrogel system for oral administration and tuned for targeted release of 5-fluorouracil (5-FU) and leucovorin calcium (LV) at colonic site. Aqueous-based free radical polymerization method was optimized first, and then a series of batches were prepared Various in vitro tests were performed to probe the characteristics of synthesized hydrogels such as the presence of functional groups, surface morphol., crystalline/amorphous properties and thermal stability which confirms the crosslinking and stability of hydrogels. Swelling, drug loading and drug release evaluations were carried out at two different pH levels of 1.2 and pH 7.4. pH responsiveness was observed in synthesized hydrogels. Co-polymeric hydrogels exhibited higher swelling and release at higher pH 7.4 as compared to lower pH 1.2. Moreover, an increased trend in swelling and drug release was observed for formulations with higher content of IA. Co-polymeric hydrogels were biocompatible and non-toxic to biol. system as investigated by acute oral toxicity study on rabbits.
Polymer Bulletin (Heidelberg, Germany) published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Computed Properties of 1492-18-8.
Referemce:
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