Yu, Jiajia; Zhang, Huihui; Wu, Xinxin; Zhu, Chen published the artcile< Intermolecular radical fluoroalkylative olefination of unactivated alkenes>, Electric Literature of 627-27-0, the main research area is vinyl preparation photochem regioselective chemoselective diastereoselective; alkene intermol radical fluoroalkylative olefination.
A novel, efficient radical-mediated intermol. fluoroalkylative olefination of inactivated alkenes RCH=CH2 [R = 2-hydroxypropan-2-yl, 1-(2-oxocyclohexyl)methyl, 3-(1-benzothiophen-2-yl)-3-oxopropyl, etc.] was disclosed. The transformation proceeded through a radical docking-migration cascade, in which a portfolio of strategically designed dual-function alkenylating reagents was harnessed to afford vinylated products RC(CH=CHR1)(C(Br)(F)(R2)) [R1 = Ph, 4-MePh, naphthalen-2-yl, etc.; R2 = CN, COOEt] with exclusive E-configuration. The reaction featured mild conditions, broad functional group compatibility, and unique chemo-, regio-, and stereoselectivities. The protocol has also provided a useful approach for late-stage olefination of complex natural products and drug derivatives containing alkenyl moieties.
CCS Chemistry published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts