Ye, Guangying; Li, Jie; Zhang, Jinhui; Liu, Hailin; Ye, Qingsheng; Wang, Zaihua published the artcile< Structural characterization and antitumor activity of a polysaccharide from Dendrobium wardianum>, Electric Literature of 3458-28-4, the main research area is erlotinib hydrochloride Dendrobium anticancer agent lung cancer; Acetylated glucomannan lung cancer cells; Anti-tumour activity; Dendrobium wardianum; Polysaccharide characteristics.
Through hot water extraction, protein removal and chromatog. purification, DWPP-Is was found to be the major polysaccharide present in the stem of D. wardianum. The Mn and Mw of DWPP-Is were 29.0 kDa and 98.6 kDa, resp. Furthermore, mannose and glucose were found to be the most abundant monosaccharides in DWPP-Is. Their backbones consist of (1 → 4)-β-D-Glcp and O-acetylated (1 → 4)-β-D-Manp, which are similar to the structures of other anti-tumor Dendrobium polysaccharides. The inhibition rate of DWPP-Is treatment on SPC-A-1 cells (2 mg/mL, 72 h) reached 56.0%. Intragastric administration of DWPP-Is on A549 tumor-bearing KM mice (10 mg/mL, 0.2 mL) exhibited similar inhibition ratios to that of erlotinib hydrochloride (2 mg/mL). Moreover, the highest inhibition was observed in P-CK treatment combined with DWPP-Is, reaching an inhibition rate of 23.4%. These results suggest that DWPP-Is has the potential to be a functional agent for lung cancer prevention.
Carbohydrate Polymers published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.
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