Xiong, Jiu-Qiang; Zhao, Chen-Yu; Qin, Jing-Yu; Cui, Pengfei; Zhong, Qiu-Lian; Ru, Shaoguo published the artcile< Metabolic perturbations of Lolium perenne L. by enrofloxacin: Bioaccumulation and multistage defense system>, Synthetic Route of 492-62-6, the main research area is glycolysis tricarboxylic acid metabolic perturbation bioaccumulation Lolium perenne; Defense systems; Ecotoxicological risks; Energy metabolism; Pasture grass; Pharmaceutical contaminants; Reclaimed water.
Plants are readily exposed to the antibiotics residues in reclaimed water indicating an urgent need to comprehensively analyze their ecotoxicol. effects and fate of these emerging contaminants. Here, we unraveled the dissemination of enrofloxacin (ENR) in a pasture grass, Lolium perenne L., and identified multistage defense systems as its adaptation mechanism. Uptaken concentrations of ENR ranged from 1.28 to 246.60μg g-1 with bioconcentration factors (BCF) upto 15.13, and translocation factors (TF) upto 0.332. The antioxidant enzymic activities such as superoxide dismutase, peroxidase, and catalase were increased by upto 115%. Further transcriptomics demonstrated that differentially expressed genes (DEGs) involved in glycolysis, tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and glutathione metabolism were significantly up-regulated by 1.56-5.93, 3-7 and 1.04-6.42 times, resp.; while, the DEGs in nitrogen and sulfur metabolism pathways were significantly up-regulated by 1.06-5.64 and 2.64-3.54 folds. These processes can supply energy, signaling mols., and antioxidants for detoxification of ENR in ryegrass. Such results provide understanding into fasting grass adaptability to antibiotics by enhancing the key protective pathways under organic pollutant stresses in environments.
Journal of Hazardous Materials published new progress about Antibiotics. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.
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