Putta, V. P. Rama Kishore; Vodnala, Nagaraju; Gujjarappa, Raghuram; Tyagi, Ujjawal; Garg, Aakriti; Gupta, Sreya; Pujar, Prasad Pralhad; Malakar, Chandi C. published the artcile< Reagent-Controlled Divergent Synthesis of 2-Amino-1,3-Benzoxazines and 2-Amino-1,3-Benzothiazines>, Computed Properties of 5344-90-1, the main research area is isothiocyanate aminobenzyl alc thiourea iodine chemoselective dehydrosulfurization cyclodehydration; benzoxazine one pot preparation; aminobenzyl alc isothiocyanate thiourea propylphosphonic anhydride chemoselective cyclodehydration; benzothiazine one pot preparation.
A reagent-controlled chemoselective process has been devised for the synthesis of 4H-1,3-benzoxazines and related biol. important heterocycles in high yields under mild conditions. These scaffolds could be efficiently constructed using two different chemoselective reactions that rely on the choice of reagents and reaction conditions. The treatment of various 2-amino-arylalkyl alcs. with isothiocyanates afforded thiourea intermediates, which were reacted in situ with mol. iodine in the presence of triethylamine to give 2-amino-4H-1,3-benzoxazines, whereas the corresponding 2-amino-4H-1,3-benzothiazines were obtained by the reaction of thiourea intermediates in the presence of T3P (a mild cyclodehydrating agent) and triethylamine as the base. The described protocol represents the first example for the synthesis of 4H-1,3-benzoxazines via the dehydrosulfurization method using mol. iodine as the reagent.
Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.
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