Niu, Yanfen; Li, Hongjian; Gao, Lihui; Lin, Hua; Kung, Hsiangfu; Lin, Marie Chia-mi; Leung, Kwong-Sak; Wong, Man-Hon; Xiong, Wenyong; Li, Ling published the artcile< old drug, new indication: olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is olsalazine sodium xanthine oxidase dehydrogenase inhibitor hyperuricemia; Hyperuricemia; Olsalazine sodium; Uric acid; Xanthine oxidase.
Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. The inhibitory activities of the ten compounds with the highest scores were tested on XOD in vitro. Interestingly, all the ten compounds inhibited the activity of XOD at certain degrees. Particularly, the anti-ulcerative-colitis drug olsalazine sodium demonstrated a great inhibitory activity for XOD (IC50 = 3.4 mg/L). Enzymic kinetic studies revealed that the drug was a hybrid-type inhibitor of xanthine oxidase. Furthermore, the drug strikingly decreased serum urate levels, serum/hepatic activities of XOD at a dose-dependent manner in vivo. Thus, we demonstrated a successful hunting process of compounds/drugs for hyperuricemia through virtual screening, supporting a potential usage of olsalazine sodium in the treatment of hyperuricemia.
Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about Gout. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts