Mudududdla, Ramesh; Jain, Shreyans K.; Bharate, Jaideep B.; Gupta, Ajai P.; Singh, Baldev; Vishwakarma, Ram A.; Bharate, Sandip B. published the artcile< ortho-Amidoalkylation of phenols via tandem one-pot approach involving oxazine intermediate>, Quality Control of 4396-13-8, the main research area is hydroxybenzyl lactam regioselective preparation; phenol lactam tandem Knoevenagel condensation Diels Alder cycloaddition; perchloric acid amidoalkylation catalyst.
An efficient method for ortho-amidoalkylation of phenols via Mannich-type condensation with formaldehyde and lactams using recyclable solid acid catalyst is described. This is the first report for ortho-amidoalkylation of phenols by lactams via Mannich-type condensation. LC-ESI-MS/MS based mechanistic study revealed that reaction proceeds through o-quinone methide (o-QM) and an oxazine intermediate via tandem Knoevenagel condensation, formal [4 + 2]-Diels-Alder cycloaddition and acid catalyzed oxazine ring-opening.
Journal of Organic Chemistry published new progress about Amidoalkylation. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Quality Control of 4396-13-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts