Lulekal, Ermias; Tesfaye, Solomon; Gebrechristos, Selam; Dires, Kassahun; Zenebe, Tizazu; Zegeye, Nigus; Feleke, Gezu; Kassahun, Abayneh; Shiferaw, Yoseph; Mekonnen, Awol published the artcile< Phytochemical analysis and evaluation of skin irritation, acute and sub-acute toxicity of Cymbopogon citratus essential oil in mice and rabbits>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is Cymbopogon skin irritation acute toxicity essential oil phytochem; Acute toxicity; Biochemical analysis; Cymbopogon citratus; Histopathology; Skin irritation; Sub-acute toxicity.
Cymbopogon citratus essential oil has been shown to have antibacterial, antifungal, antiprotozoal, anti-carcinogenic, anti-inflammatory and antioxidant activities amongst others. This study was conducted to determine skin irritation, acute and subacute toxicity of C. citratus essential oil in mice and rabbits. The essential oil was analyzed using GC-MS. The essential oil at dose of 2000 mg/kg body weight was administered to mice for 21 consecutive days. The mice mortality, behavioral change, injury and other signs of illness were recorded once daily. Biochem. parameters were evaluated. Liver and kidney were taken after sacrifice for gross findings and histol. analyses. 10% ointment formulation of C. citratus oils was applied on the rabbit skin to determine skin irritation effects. The result revealed, the presence of citral (71.297%), myrcene (19.034%), 4, 5-epoxycarene (2.780%), linalool (1.713%), (S)-cis-verbenol (1.110%), linalool (1.713%), (S)-cis-verbenol (1.110%) and undecan-2-one (1.001%) in the C. citratus essential oil. There was no significant difference (p > 0.05) in the body weights, gross abnormalities of the organs and biochem. parameters compared to the control. No histopathol. changes were detected in the organs tested. 10% ointment formulation of C. citratus oils did not cause skin irritation. Anal. of results leads to the conclusion that Ethiopian C. citratus essential oil may be considered as relatively safe and non-toxic.
Toxicology Reports published new progress about Acute toxicity. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.
Referemce:
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Alcohols – Chemistry LibreTexts