Liu, Chao; Song, Liangliang; Peshkov, Vsevolod A.; Van der Eycken, Erik V. published the artcile< Transition metal-free selective C-S bond cleavage of Ugi-adducts for rapid preparation of peptidomimetics>, SDS of cas: 627-27-0, the main research area is peptidomimetic aminal synthesis natural product; Ugi adduct Mannich reaction copper catalyst reaction bond cleavage; Mannich reaction mechanism deprotonation.
A transition metal-free C-S bond cleavage and subsequent Mannich reaction of Ugi-adducts with alcs. as well as thiols is developed. Diverse novel peptidomimetics containing N,O- or N,S-aminals are synthesized in a rapid, highly efficient and step-economical fashion. This method features exclusive selectivity, broad substrate scope, excellent yield and functional group tolerance, and was applied on substrates derived from the pharmaceuticals febuxostat, probenecid and memantine.
Green Chemistry published new progress about Aminals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts