Smoum, Reem;Haj, Christeene;Hirsch, Shira;Nemirovski, Alina;Yekhtin, Zhannah;Bogoslavsky, Benny;Bakshi, Gaganjyot Kaur;Chourasia, Mukesh;Gallily, Ruth;Tam, Joseph;Mechoulam, Raphael published 《Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential》 in 2022. The article was appeared in 《Molecules》. They have made some progress in their research.Product Details of 80-46-6 The article mentions the following:
A series of novel cannabinoid-type derivatives was synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(-)-fenchones I (R = H, Me, n-pentyl, 2-methylbutan-2-yl, etc.; R1 = H, hexyl; R2 = H, OMe) with various resorcinols RC6H3(OH)2/phenols RC6H4OH. The fenchone-resorcinol derivatives I were fluorinated using Selectfluor and demethylated using sodium ethanethiolate in DMF (DMF). The absolute configurations of four compounds were determined by X-ray single crystal diffraction. The fenchone-resorcinol analogs I possessed high affinity and selectivity for the CB2 cannabinoid receptor. One of the analogs synthesized, I (R = 2-methyloctan-2-yl, R1 = H, R2 = OMe (II)), had a high affinity (Ki = 3.51 nM) and selectivity for the human CB2 receptor (hCB2). In the [35S]GTPγS binding assay, the lead compound was found to be a highly potent and efficacious hCB2 receptor agonist (EC50 = 2.59 nM, E(max) = 89.6%). Two of the fenchone derivatives I were found to possess anti-inflammatory and analgesic properties. Mol.-modeling studies elucidated the binding interactions of (II) within the CB2 binding site.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.
4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Product Details of 80-46-6
Reference:
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