Larsen, Finn Ole; Jensen, Benny V.; Norgaard, Hans Henrik; Hermann, Helle Kirstine; Larsen, Peter N.; Markussen, Alice; Hogdall, Estrid; Nielsen, Dorte published the artcile< Intrahepatic Oxaliplatin and Systemic 5-FU +/- Cetuximab in Chemo-Naive Patients with Liver Metastases from Colorectal Cancer>, COA of Formula: C20H21CaN7O7, the main research area is oxaliplatin fluorouracil cetuximab anticancer agent liver metastasis colorectal cancer; Colorectal cancer; Intrahepatic infusion; Oxaliplatin; Transarterial chemoembolization.
In case of response to chemotherapy, unresectable liver metastases from colorectal cancer can be converted to resectable and thereby obtain a chance of cure. The primary aim of this trial was to evaluate the response rate with intrahepatic oxaliplatin in combination with systemic 5-FU +/- cetuximab. Secondary aims were to evaluate the conversion rate from unresectable to resectable liver metastases, median progression-free survival, median overall survival, and toxicity. Forty-five chemo-naive patients with liver metastases from colorectal cancer were treated in a prospective phase II trial. Calcium folinate and 5-FU were delivered systemically while oxaliplatin was delivered alternating between systemic and intrahepatic administration. When oxaliplatin was delivered intrahepatic-ally, infusion time was reduced to 10 min followed by embolic material. In patients with KRAS wild-type tumors, cetuximab was added. The treatment was well tolerated and only pain in the liver and a mild increase in liver enzymes were observed after intrahepatic oxaliplatin. The patients obtained a response rate of 82%. Further, 58% converted from having unresectable to resectable liver metastases. The median overall survival and progression-free survival were 38.7 mo (95% confidence interval [CI] 33.0-44.3) and 12.9 mo (95% CI 10.2-15.6), resp. Intrahepatic infusion of oxaliplatin in 10 min with systemic 5-FU to patients with chemo-naive colorectal cancer is feasible and with low toxicity. A high response rate and long median overall survival were obtained.
Oncology published new progress about Animal gene, N-ras Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, COA of Formula: C20H21CaN7O7.
Referemce:
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Alcohols – Chemistry LibreTexts