Kleban, Ihor; Krokhmaliuk, Yevhen; Reut, Sofiia; Shuvakin, Serhii; Pendyukh, Vyacheslav V.; Khyzhan, Oleksandr I.; Yarmoliuk, Dmytro S.; Tymtsunik, Andriy V.; Rassukana, Yuliya V.; Grygorenko, Oleksandr O. published the artcile< Multigram Synthesis of Heterabicyclo[n.1.0]alkan-1-yl Trifluoroborates>, Application of C4H8O, the main research area is enyne hetero preparation hydroboration; bromoallyl derivative preparation lithiation borylation; heterabicycloalkanyl trifluoroborate preparation.
An approach to the synthesis of oxa- and azabicyclo[n.1.0]alkan-1-yl trifluoroborates on a multigram scale was developed. Two synthetic strategies were evaluated: the 1st based on the lithiation-borylation of the corresponding 2-bromoallyl derivatives, and the other relying on regioselective hydroboration of the appropriate hetera-substituted enynes. The 2nd method appeared to be more efficient in terms of scalability and substrate scope. Further steps included ring closing-metathesis, mild Pd-catalyzed cyclopropanation with diazomethane, and reaction with KHF2 and furnished the title compounds in up to 50 g scale in a single run (10-41% overall yield, 4-5 steps).
European Journal of Organic Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.
Referemce:
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Alcohols – Chemistry LibreTexts