Jung, Jong-Woon; Damodar, Kongara; Kim, Jin-Kyung; Jun, Jong-Gab published the artcile< First synthesis and in vitro biological assessment of isosideroxylin, 6,8-dimethylgenistein and their analogues as nitric oxide production inhibition agents>, Related Products of 4396-13-8, the main research area is isosideroxylin preparation nitric oxide inhibitory antiinflammatory activity; dimethylgenistein preparation nitric oxide inhibitory antiinflammatory activity; Vilsmeier Haack Friedel Crafts acylation Gammill protocol Suzuki.
A modular and efficient synthesis of the biol. significant C-methylisoflavones isosideroxylin (I), 6,8-dimethylgenistein (II) and their analogs is established for the first time. The synthesis is realized in 7-8 steps in overall yields of 16%-24% from com. inexpensive phloroglucinol and features a high yielding Vilsmeier-Haack reaction, Friedel-Crafts acylation, Gammill’s protocol and Suzuki coupling as the pivotal transformations. Next, these compounds evaluated for their inhibitory potency on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW-264.7 cells as an indicator of anti-inflammatory activity. The results showed that all the compounds decreased NO production in a dose-dependent manner without marked cytotoxicity and IC50 values are found in the range of 10.17-33.88 μmol/L. Of note, some compounds show comparable inhibitory activity with pos. control (N-monomethyl-L-arginine, L-NMMA).
Chinese Chemical Letters published new progress about Anti-inflammatory agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts