Jowett, Laura A.; Howe, Ethan N. W.; Soto-Cerrato, Vanessa; Van Rossom, Wim; Perez-Tomas, Ricardo; Gale, Philip A. published the artcile< Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents>, Quality Control of 35564-86-4, the main research area is breast cancer perenosin hydrogen chloride transporter anticancer cytotoxicity.
Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesized a new class of H+/Cl- cotransporters named ‘perenosins’. Here we report a new library of indole-based perenosins and their anion transport properties. The new transporters demonstrated superior transmembrane transport efficiency when compared to other indole-based transporters, due to favorable encapsulating effects from the substituents on the perenosin backbone. Anion transport assays were used to determine the mechanism of chloride transport revealing that the compounds function as ‘strict’ HCl cotransporters. Cell viability studies showed that some compounds specifically trigger late-onset cell death after 72 h with a unique correlation to the position of alkyl chains on the perenosins. Further investigations of cell death mechanism showed a mixture of cell cycle arrest and apoptosis was responsible for the observed decrease in cell viability.
Scientific Reports published new progress about Antitumor agents. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Quality Control of 35564-86-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts