Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Determination of antioxidants in food and water-based food simulants by supercritical fluid chromatography》 was published in 2021. The authors were Huang, Lin;Xiao, Lei;Zhu, Yan;Shou, Dan;Jin, Micong;Han, Xinghao, and the article was included in《Fenxi Shiyanshi》. The author mentioned the following in the article:
A novel pretreatment method based on syringe for filter solid-phase extraction was developed and combined with supercritical fluid chromatog. (SFC) to determine the migration of antioxidants in packaging materials to two water-based food simulants, and applied to test real sample. The amount of sorbent and SFC conditions were optimized. Under the optimized conditions, all the studied six target antioxidants have good linearity (R2>0.999) in their resp. concentration ranges with limits of detection (LODs) ranging from 25 to 35 ng/mL. Mean recoveries of targets were between 82.0% and 96.0% in ultrapure water, and between 76.2% and 103.0% in 3% acetic acid solution, with the relative standard deviations (RSD) no more than 8.8%. The method is adaptable for analyzing the antioxidants in com. non-alc. beverage and their packaging materials (soaking in different food simulants). The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .
Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts