Huang, Kang; Wang, Yuegang; Bai, Yang; Luo, Qiuyan; Lin, xuancai; Yang, Qiuyu; Wang, Shihao; Xin, hongjie published the artcile< Gut microbiota and metabolites in atrial fibrillation patients and their changes after catheter ablation>, Category: alcohols-buliding-blocks, the main research area is microbiota metabolite catheter ablation human atrial fibrillation; atrial fibrillation; gut metabolites; gut microbiota.
The gut microbiota has been shown to be associated with multiple cardiovascular diseases, but there is little research on the gut microbiota and atrial fibrillation (AF); thus, how the gut microbiota and metabolites change in AF patients after catheter ablation is unclear. In this study, we used 16S rRNA high-throughput sequencing and nontargeted metabolomic detection to conduct horizontal and longitudinal analyses of the gut microbiota and metabolites of AF patients. Compared with a control group, species richness and diversity increased significantly in AF patients. Among them, opportunistic pathogenic bacteria, such as Klebsiella, Haemophilus,Streptococcus, and Enterococcus, were significantly increased, and symbiotic bacteria, such as Agathobacter and Butyrivibrio, were significantly reduced. After catheter ablation, intestinal symbiotic bacteria (Lactobacillus, Agathobacter, Lachnospira, etc.) were increased in most AF patients, while pathogenic bacteria (Ruminococcus, etc.) were reduced. Moreover, in AF patients, caffeine, which was neg. correlated with Klebsiella, was downregulated, and estradiol and ascorbic acid, which were pos. correlated with Agathobacter, were also downregulated. After catheter ablation, citrulline, which was pos. correlated with Ralstonia and Lactobacillus, was increased. Oleanolic acid, which was neg. correlated with Ralstonia was downregulated. In conclusion, our results not only show overall changes in the gut microbiota and metabolites in AF patients but also indicate their changes in the short term after catheter ablation. These data will provide novel possibilities for the future clin. diagnosis and treatment of AF.
Microbiology Spectrum published new progress about Ablation (catheter). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.
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