Category: alcohols-buliding-blocksIn 2020, Wang, Mingyang;Li, Man;Yang, Shan;Xue, Xiao-Song;Wu, Xinxin;Zhu, Chen published 《Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity》. 《Nature Communications》published the findings. The article contains the following contents:
Herein, an efficient strategy for the direct C-C cleavage of cyclohexanones and cyclopentanones, e.g., I [X = O, CH2; Z = CH2, CH2CH2, (CH2)3; R = H, 4-Ph, 3,5-Cl2, etc.], is reported. The cyclic C-C σ-bond is readily cleaved under mild conditions with the aid of an in situ formed side-chain aryl radical. D. functional theory calculations are carried out to shed light on the unusual regioselectivity of C-C bond cleavage. The reaction affords a variety of structurally diverse 3-coumaranones and indanones II that widely exist in natural products and bioactive mols., illustrating the synthetic value of this method.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.
4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Category: alcohols-buliding-blocks 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts