Donthireddy, S. N. R.; Singh, Vivek Kumar; Rit, Arnab published the artcile< A heteroditopic NHC and phosphine ligand supported ruthenium(II)-complex: an effective catalyst for the N-alkylation of amides using alcohols>, Name: (2-Aminophenyl)methanol, the main research area is alkylation aromatic amide aralkyl alc ruthenium chelate carbene catalyst; ruthenium imidazolylidene triazolylidene mesoionic carbene preparation amide alkylation catalyst; secondary aromatic amide benzyl preparation alkylation arenemethanol ruthenium catalyst.
A ruthenium(II) complexes [(p-cymene)RuCl(1-MeIm-3-CH2Trz-1-C6H4R)] (Im = 2-imidazolylidene, Trz = 1,2,3-triazol-4-yl-5-ylidene; R = 2,4,6-Me3, 4-MeO, 4-CF3) supported by chelate NHC and mesoionic carbene ligands in combination with a diphosphine ligand (dppe, dppf) was shown to be a highly effective catalyst for the N-alkylation of diverse aromatic amides ArCONH2 using readily available primary aralkyl alcs. Ar1CH2OH, yielding N-benzylamides ArCONHCH2Ar1 (Ar, Ar1 = substituted Ph, pyridyl, thienyl, naphthyl). A wide range of secondary amides was thus obtained in excellent yields (up to 98%) employing a low catalyst loading of 0.2 mol% and a substoichiometric amount of base. The 1H NMR and ESI-MS analyses support the participation of a N-heterocyclic carbene and phosphine supported Ru-H species in the catalytic cycle and the mechanistic studies including the deuterium labeling experiment suggest the involvement of a borrowing hydrogen protocol. Addnl., the present catalytic system was also revealed to be efficient for the selective mono-alkylation and unsym. di-alkylation of 4-aminobenzamides which have not been studied before to the extent of our knowledge.
Catalysis Science & Technology published new progress about Alkylation catalysts. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.
Referemce:
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