Dang, Huiping; Tian, Youliang; Cheng, Quan; Teng, Changchang; Xie, Kai; Yan, Lifeng published the artcile< Galactose conjugated boron dipyrromethene and hydrogen bonding promoted J-aggregates for efficiently targeted NIR-II fluorescence assistant photothermal therapy>, Computed Properties of 4064-06-6, the main research area is galactose conjugated boron dipyrromethene hydrogen bond fluorecence tumor imaging; 4, 4-difluoro-4-bora-3a, 4a-diazas-indacene (BODIPY); Galactose conjugated; Imaging-guided; NIR-II fluorescence; Photothermal therapy.
It is essential to develop novel multifunctional and easily synthesized stable NIR-II fluorescent probes to guide photothermal therapy for tumors. Here, we propose a new strategy to construct boron dipyrromethene (BODIPY) J-aggregates by intermol. hydrogen bonding (H-bond) and π-π stacking interactions to achieve fluorescence emission in the second near-IR window (NIR-II, 1000-1700 nm). A novel meso-benzamide galactose hexanoate-BODIPY (Gal-OH-BDP) amphiphilic small mol. dye was synthesized and it formed nanoparticles spontaneously in aqueous solution with a maximum emission wavelength near 1060 nm, which works as a smart nanomedicine for targeting NIR-II imaging-guided photothermal therapy (PTT) of hepatocellular carcinoma. Galactose not only provided hydrogen bonds to regulate the aggregation pattern of the mols. but also effectively targeted hepatocellular carcinoma cells and promoted the formation of well-dispersed nanoparticles of dye mols. due to their hydrophilicity. Moreover, due to high photothermal conversion efficiency (PCE = 55%), Gal-OH-BDP NPs achieve galactose-targeted NIR-II imaging and PTT, which is important for the precise diagnosis and treatment of tumors (Scheme 1). In the present research work, H-bond was introduced for the first time into BODIPY for building J-aggregates to achieve the NIR-II fluorescence.
Journal of Colloid and Interface Science published new progress about Cytotoxicity. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Computed Properties of 4064-06-6.
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