da Silva, Mateus V. C.; Souza, Amanda B.; de Castro, Heizir F.; Aguiar, Leandro G.; de Oliveira, Pedro C.; de Freitas, Larissa published the artcile< Synthesis of 2-ethylhexyl oleate catalyzed by Candida antarctica lipase immobilized on a magnetic polymer support in continuous flow>, Reference of 104-76-7, the main research area is ethylhexyl oleate Candida antarctica lipase immobilization; Esterification; Immobilized lipase; Kinetic modeling; Magnetic polymer; Packed-bed reactor.
This study investigated the synthesis of 2-ethylhexyl oleate catalyzed by Candida antarctica lipase immobilized on magnetic poly(styrene-co-divinylbenzene) particles in a continuous packed-bed bioreactor. Runs were carried out in a solvent-free system at 50°C. The performance of the reactor was evaluated for substrates composed by oleic acid and 2-ethylhexanol at five molar ratios (1:4-4:1), determining its operation limits in terms of substrate flow rate. The system performance was quantified for three different flow rates corresponding to space-time between 3 and 12 h. For each condition, the influence of the space-time in the ester formation, esterification yield and productivity was determined The molar ratio of acid-to-alc. interfered, in a remarkable way, in the formation of 2-ethylhexyl oleate and the best performance was attained for substrate at equimolar ratio running at 12 h space-time. Under this condition, average 2-ethylhexyl oleate concentration was 471.65 ± 2.98 g L-1 which corresponded to ester productivity of 23.16 ± 0.49 mmol g-1 L-1 h-1. This strategy also gave high biocatalyst operational stability, revealing a half-life time of 2063 h. A model based on the ping-pong Bi-Bi mechanism was developed to describe the kinetics of the esterification reaction and validated using exptl. data. The goodness of fit of the model was satisfactory (R2 = 0.9310-0.9952).
Bioprocess and Biosystems Engineering published new progress about Growth, microbial. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Reference of 104-76-7.
Referemce:
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Alcohols – Chemistry LibreTexts